Systemic Lupus Erythematosus and The Skin

Ohikhuare Okun¹, Kenechukwu Anthony Ibenegbu², Igbinomwanhia Osahon Rex³, Mba Nkiruka Ikpo⁴, Michael Omo Osunsedo^2*, Nnekachi Prayer Nnokam⁵

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs, including the skin. Cutaneous manifestations are common in SLE, affecting up to 85% of patients, and can significantly impact quality of life. This review discusses the various skin symptoms associated with SLE, including malar rash, discoid lupus erythematosus, photosensitivity, alopecia, and oral ulcers. Understanding the pathogenesis and treatment options for cutaneous lupus is essential for effective management of the disease. A comprehensive treatment plan that incorporates topical and systemic therapies, lifestyle modifications, and recent advances in treatment options can help improve patient outcomes.

Keywords

systemic lupus erythematosus (SLE); cutaneous lupus; skin manifestations; autoimmune disease; treatment strategies.

Cite This Article

Okun, O., Ibenegbu, K. A., Rex, I. O., Ikpo, M. N., Osunsedo, M. O., Nnokam, N. P. (2025). Systemic Lupus Erythematosus and The Skin. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 4: Jul – Aug 2025, Pages 717-720 URL: https://www.ijscia.com/wp-content/uploads/2025/07/Volume6-Issue4-Jul-Aug-No.917-717-720.pdf

Volume 6 | Issue 4: Jul – Aug 2025