Primary Singnet Ring Cell Carcinoma with Thyroid Storm: A Case Report
I Gusti Bagus Dharma Prakasa Musti1*, Gede Eka Rusdi Antara2, Anak Agung Ketut Lanang Ari Mayun3
Abstract
Background: Signet ring cell carcinoma (SRCC) of the colon and rectum comprises 0.1–2.6% of colorectal cancers. Most cases are found at advanced stages and rarely at early stages. SRCC are commonly found in the stomach (95%), but can also be seen in the colon, rectum, ovary, peritoneum, and gallbladder. We present a case of primary SRCC of the tranfersum colon with hyperthyroidism caused by thyroid storm. Case: A 52-year-old female presented with abdominal pain and unintentional weight loss. Computed tomography scan of the abdomen and pelvis demonstrated a tranfersum colon mass with partial small bowel obstruction and enlarged lymph nodes adjacent to the colon without any other metastatic disease. Colonoscopy revealed a partial obstruction of the colon tranfersum. Tumor resection and anastomosis of the tranfersum the colon was performed. Pathology revealed malignant cells exhibiting signet ring morphology. The patient had hyperthyroidism before surgery, which caused post-operative thyroid storm. Discussion: Thyroid storm is an endocrine emergency that is characterized by multiple organ failure due to severe thyrotoxicosis, often associated with triggering illnesses. Early suspicion, prompt diagnosis, and intensive treatment will improve survival in thyroid storm patients. Primary SRCC is associated with a poor prognosis. This is attributed to being typically diagnosed at advanced stages. The factors causing the delay in diagnosis include the rarity of this tumor, intramucosal tumor spread with relative mucosal sparing, minimal symptoms, and the tumor resembling an inflammatory process on radiographic imaging. At advanced stages, the median and mean survival times are 20 and 45 months, respectively. In the case report, we described a rare case of primary signet ring cell carcinoma of the colon with hyperthyroidism caused by thyroid storm.
Keywords
Signet ring cell carcinoma; Colorectal cancer; Hyperthyroidism; Thyroid storm.
Cite This Article
Musti, I. G. B. D. P., Antara, G. E. R., & Mayun, A. A. K. L. (2025). Primary Singnet Ring Cell Carcinoma with Thyroid Storm: A Case Report. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 5: Sep – Oct 2025, Pages 893-896 URL: https://www.ijscia.com/wp-content/uploads/2025/09/Volume6-Issue5-Sep-Oct-No.946-893-896.pdf
Volume 6 | Issue 5: Sep – Oct 2025
