The Role of ALS3 Gene in C. albicans Biofilm and Its Management Strategies: A Literature Review

Ni Putu Kusuma Santhi Y.*, Ida Bagus Nyoman Putra Dwija

Abstract

Candida albicans is an opportunistic fungus that can cause infections in humans, ranging from mild mucosal infections to life-threatening systemic infections. One of the key factors in the pathogenesis of C. albicans is its ability to form biofilms, a structure that provides protection against the immune system and antifungal treatments. Biofilm formation involves the interaction between fungal cells and a complex extracellular matrix, as well as adhesion genes such as ALS3. The ALS3 gene encodes the Als3 protein, which plays a role in the adhesion of C. albicans cells to surfaces and the morphological transition from yeast to filamentous form, both of which are crucial for biofilm stability. Anti-biofilm therapies targeting the ALS3 gene or the extracellular matrix have the potential to enhance the effectiveness of C. albicans treatment and reduce resistance to antifungal therapies. A deeper understanding of biofilm formation mechanisms in C. albicans will open up opportunities for the development of more effective therapies to address this fungal infection, particularly in patients with compromised immune systems.

Keywords

C.albiacans; biofilm; Als3

Cite This Article

Santhi Y., N. P. K., Dwija, I. B. N. P. (2025). The Role of ALS3 Gene in C. albicans Biofilm and Its Management Strategies: A Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 6: Nov – Dec 2025, Pages 1258-1261 URL: https://www.ijscia.com/wp-content/uploads/2025/12/Volume6-Issue6-Nov-Dec-No.1003-1258-1261.pdf

Volume 6 | Issue 6: Nov – Dec 2025