Carbohydrate and Lipid Metabolic Profiles in Hospitalized Pulmonary Tuberculosis Patients at Dr. Soetomo General Academic Hospital, Indonesia: A Comparative Study with Healthy Control
Nur Husnina Jafni1, Manik Retno Wahyunitisari2*, Herley Windo Setiawan3,4, Ariani Permatasari3,5
Abstract
Introduction: Tuberculosis (TB) is an infectious disease that can affect various organs, especially the lungs and is caused by Mycobacterium tuberculosis. TB patients experience changes in carbohydrate and lipid metabolism as a result of metabolic modulation by Mtb in order to survive in the host body. Objective: To analyze the differences in carbohydrate and lipid metabolic profiles between pulmonary TB patients in the inpatient ward compared to healthy controls. Methods: This study is a retrospective observational analytical study with a case-control design using secondary data in the form of electronic medical records of patients at Dr. Soetomo General Academic Hospital in 2024, with variables including fasting plasma glucose, total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride. Result: Most hospitalized pulmonary TB patients were male (60.5%) with the largest age range being 45-59 years (39.5%). Most pulmonary TB patients had a normal BMI (63.2%) and rifampicin-sensitive results in GeneXpert MTB/RIF (78.9%). Comparison test results showed no significant differences in glucose (p = 0.108) and triglyceride (p = 0.496) levels between the case and control groups. However, significant differences were found in total cholesterol levels (p < 0.001), HDL (p < 0.001), and LDL (p = 0.014). Conclusion: There were significant differences in lipid metabolism profiles, especially in total cholesterol, HDL, and LDL levels, between pulmonary TB patients hospitalized and the healthy control group. However, no significant differences were found in fasting plasma glucose and triglyceride levels.
Keywords
tuberculosis; metabolism; fasting plasma glucose; lipid profile
Cite This Article
Jafni, N. H., Wahyunitisari, M. R., Setiawan, H. W., Permatasari, A. (2026). Carbohydrate and Lipid Metabolic Profiles in Hospitalized Pulmonary Tuberculosis Patients at Dr. Soetomo General Academic Hospital, Indonesia: A Comparative Study with Healthy Control. International Journal of Scientific Advances (IJSCIA), Volume 7| Issue 4: Jul – Aug 2026, Pages 433-439 URL: https://www.ijscia.com/wp-content/uploads/2026/07/Volume7-Issue4-Jul-Aug-No.1059-433-439.pdf
Volume 7 | Issue 4: Jul – Aug 2026
