Antibacterial Potential of Sargassum crassifolium Against Salmonella Typhi: A Narrative Review
Faizza Najmi Ha-atiansyah Kusuma1, Agung Dwi Wahyu Widodo2*
Abstract
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a global health problem, and antimicrobial resistance is narrowing treatment options. Sargassum crassifolium, a brown alga rich in metabolites, has been reported to have antibacterial activity, but its relevance to S. Typhi is unclear. This narrative review examines the evidence for the antibacterial activity of S. crassifolium against Salmonella, distinguishing direct from indirect evidence. S. crassifolium showed in vitro activity against several non-Salmonella bacteria, and the activity varied with the extraction solvent. One study reported inhibition of Salmonella sp. without confirming the serovar; one study tested laminaran against S. Typhimurium, and the studies on S. Typhi identified the alga only to the genus level. The current evidence is therefore insufficient to conclude that S. crassifolium is specifically active against S. Typhi. Further research needs authenticated algal material, well-defined bacterial strains, standardized methods, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) measurements, and safety testing.
Keywords
Sargassum crassifolium; Salmonella Typhi; typhoid fever
Cite This Article
Kusuma, F. N. H., Widodo, A. D. W. (2026). Antibacterial Potential of Sargassum crassifolium Against Salmonella Typhi: A Narrative Review. International Journal of Scientific Advances (IJSCIA), Volume 7| Issue 6: Nov – Dec 2026, Pages 1026-1029. URL: https://www.ijscia.com/wp-content/uploads/2026/11/Volume7-Issue6-Nov-Dec-No.1125-1026-1029.pdf
Volume 7 | Issue 6: Nov – Dec 2026
