Bloodstream Infections in Hematologic Malignancies: Clinical Features and Pathogen Profile from a 2023 Study at Dr. Soetomo General Hospital, Surabaya
Almirasnya Nafeeza Heriqbaldi1, Pepy Dwi Endraswari2*, Pradana Zaky Romadhon3, Siprianus Ugroseno Yudho Bintoro4
Abstract
Infection remains a major complication and a leading cause of death in patients with hematologic malignancies (HMs), with bloodstream infection (BSI) being one of the most critical complications. This happens due to profound immunosuppression caused by the disease and chemotherapy. Myelosuppression and neutropenia significantly increase the risk of infection in these patients. This retrospective descriptive study analyzed 129 patients with HMs and positive blood cultures at Dr. Soetomo General Hospital, Surabaya, in 2023 to describe the clinical profile and pathogen distribution. The findings showed that most patients were male, aged 19-59 years, and most were diagnosed with acute lymphocytic leukemia (ALL) and had a history of chemotherapy exposure. Hematologic profile showed high rates of anemia, thrombocytopenia, and neutropenia. A total of 142 isolates showed Gram-positive bacteria were the most common pathogens, with Staphylococcus aureus as the predominant species, and most infections being monomicrobial. Antibiotic susceptibility tests showed variable resistance patterns. These findings highlight the vulnerability of patients with HMs to severe infections and the need for optimized infection prevention and surveillance of local pathogen and antibiotic sensitivity patterns.
Keywords
hematologic malignancy; bloodstream infection pathogen; neutropenia
Cite This Article
Heriqbaldi, A. N., Endraswari, P. D., Romadhon, P. Z., Bintoro, S. U. Y. (2025). Bloodstream Infections in Hematologic Malignancies: Clinical Features and Pathogen Profile from a 2023 Study at Dr. Soetomo General Hospital, Surabaya. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 6: Nov – Dec 2025, Pages 1227-1239 URL: https://www.ijscia.com/wp-content/uploads/2025/12/Volume6-Issue6-Nov-Dec-No.999-1227-1239.pdf
Volume 6 | Issue 6: Nov – Dec 2025
