Central Precocious Puberty: Case Report of a 6-Year-Old Girl
Calista Dinda Natania Rau1, Delicia Rudy1, I Wayan Bikin Suryawan2
Abstract
Background: Central precocious puberty (CPP) is a condition characterized by the early appearance of secondary puberty signs before the expected age, caused by premature activation of the hypothalamic-pituitary-gonadal axis. This condition can impact the child’s physical growth, psychosocial development, and long-term health, requiring a comprehensive diagnostic approach. Case: A 6-year-old girl presented with a lump in the left breast without pain or other signs of inflammation. Physical examination showed Tanner stage M2P1 puberty status. Laboratory results indicated LH levels of 0.31 mIU/mL, FSH 5.52 mIU/mL, and Estradiol 10.99 pg/mL. Radiological bone age assessment showed consistency with an age of 5 years and 9 months. The diagnosis of CPP was established based on anamnesis, physical examination, and hormonal profile, although bone age did not show significant advancement. The patient received intramuscular Medroxyprogesterone therapy. Conclusion: The diagnosis of CPP is not always accompanied by accelerated bone age. A comprehensive evaluation, including anamnesis, pubertal status, and hormonal profiling, remains the key to establishing the diagnosis. Early detection and intervention are important to prevent long-term impacts on the child’s growth and psychosocial development.
Keywords
precocious puberty; bone age; gonadotropin hormones; Tanner stage; diagnosis; early.
Cite This Article
Rau, C. D. N., R., Rudy, D., Suryawan, I. W. B. (2025). Central Precocious Puberty: Case Report of a 6-Year-Old Girl. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 3: May-Jun 2025, Pages 630-633 URL: https://www.ijscia.com/wp-content/uploads/2025/06/Volume6-Issue3-May-Jun-No.903-630-633.pdf Volume 6 | Issue 3: May – Jun 2025
