The Effect of Adjunctive Vitamin D Supplementation on Disease Severity in Chronic Spontaneous Urticaria: A Literature Review

Idfi Aliya Sausan Fadhila¹*, Dwi Aprilawati²*, Sylvia Anggraeni³

Abstract

Vitamin D has been investigated as an adjunctive treatment for chronic spontaneous urticaria (CSU), although an association between low vitamin D concentrations and CSU does not establish that supplementation improves disease severity. This review aimed to critically evaluate the evidence regarding adjunctive vitamin D supplementation and disease severity in CSU, including its effects on quality of life, safety, and clinical applicability. A narrative literature review was conducted through targeted scholarly searches and verification of relevant primary studies, evidence syntheses, and international guidelines, with searches completed on 31 October 2026. Randomized trials were distinguished from uncontrolled before–after studies, while observational and mechanistic findings were considered contextual evidence. Several studies reported reductions in urticaria activity and symptom severity following supplementation. A placebo-controlled trial involving vitamin-D-deficient patients demonstrated improvement in UAS7, whereas comparisons of high- and low-dose supplementation did not consistently demonstrate superiority in final disease severity outcomes. Improvements in quality of life were reported in some studies, but medication-sparing effects remained uncertain. Interpretation was limited by small or selected populations, heterogeneous outcome measures, active-dose comparators, and short follow-up periods. Furthermore, hypercalcemia and renal lithiasis were reported in individual trials. In conclusion, adjunctive vitamin D may reduce short-term disease activity in some patients with CSU, particularly those with low vitamin D status. However, the magnitude and durability of its benefits, optimal supplementation regimen, and predictive value of baseline vitamin D levels remain uncertain. Current evidence does not support routine high-dose supplementation for all patients or its use as a replacement for established CSU treatments.

Keywords

chronic spontaneous urticaria; vitamin D supplement; biological plausibility of vitamin D  

Cite This Article

Fadhila, I. A. S., Aprilawati, D., Anggraeni, S. (2026). The Effect of Adjunctive Vitamin D Supplementation on Disease Severity in Chronic Spontaneous Urticaria: A Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 7| Issue 6: Nov – Dec 2026, Pages 1063-1068. URL: https://www.ijscia.com/wp-content/uploads/2026/11/Volume7-Issue6-Nov-Dec-No.1130-1063-1068.pdf

Volume 7 | Issue 6: Nov – Dec 2026