Effect of Combined Resistance and Endurance Exercise Training on Oxidative Stress in Individuals with Obesity: A Literature Review

I Ketut Bagus Sajjana Vandhana Pamecut¹, Purwo Sri Rejeki^2*

Abstract

Obesity is a complex metabolic disorder characterized by excessive adiposity, chronic low-grade inflammation, and increased oxidative stress. These processes contribute to insulin resistance, endothelial dysfunction, and metabolic comorbidities. Training is a non-pharmacological intervention, with endurance training promoting mitochondrial function and cardiovascular health, and resistance training supporting gains in skeletal muscle mass, strength, and glucose metabolism. Recent studies indicate that combined resistance and endurance training may produce synergistic benefits by enhancing antioxidant defenses, reducing reactive oxygen species (ROS), and improving metabolic regulation. This narrative review synthesizes current evidence on the effects of combined training on oxidative stress in individuals with obesity, examining molecular mechanisms, biomarkers of oxidative damage and antioxidant capacity, and implications for metabolic health. The review highlights combined training as an effective non-pharmacological strategy to mitigate obesity-associated oxidative stress, restore redox balance, and improve overall metabolic outcomes.

Keywords

combined training; obesity; oxidative stress; reactive oxygen species; antioxidant defenses; literature review

Cite This Article

Pamecut, I. K. B. S. V., Rejeki, P. S. (2025). Effect of Combined Resistance and Endurance Exercise Training on Oxidative Stress in Individuals with Obesity: A Literature Review. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 6: Nov – Dec 2025, Pages 1095-1099 URL: https://www.ijscia.com/wp-content/uploads/2025/11/Volume6-Issue6-Nov-Dec-No.979-1095-1099.pdf

Volume 6 | Issue 6: Nov – Dec 2025