Factors Associated with Retinopathy of Prematurity Based on Laboratory Findings at Dr. Soetomo Hospital, Indonesia
Aqila Sabila Rusyda1, Reni Prastyani2*, Kartika Darma Handayani3, Rozalina Loebis2
Abstract
Background: Retinopathy of Prematurity (ROP) is a leading cause of preventable blindness among preterm infants, with a relatively high prevalence in Indonesia. Although various risk factors have been investigated, evidence regarding laboratory findings as potential predictors of ROP remains limited. Objective: This study aimed to determine the association between laboratory parameters and the occurrence of ROP in preterm infants admitted to Dr. Soetomo General Academic Hospital from January 2023 to June 2024. Methods: This study is a descriptive-analytic study with a retrospective design, with independent variables including hemoglobin, leukocyte, thrombocyte count, and random blood glucose, while the dependent variable was the occurrence of ROP. Results: Among 312 infants, 70 (22.4%) developed ROP, and there was no significant associations were found between ROP and hemoglobin (p = 0.600), leukocyte (p = 0.943), thrombocyte (p = 0.264), or random blood glucose (p = 0.804). Conclusion: Laboratory parameters were not directly associated with the occurrence or severity of ROP. The main determinants of ROP were lower gestational age and birth weight, while blood transfusion and sepsis acted as additional contributing factors.
Keywords
retinopathy of Prematurity; associated factors; laboratory findings; prematurity
Cite This Article
Rusyda, A. S., Prastyani, R., Handayani, K. D., Loebis, R. (2025). Factors Associated with Retinopathy of Prematurity Based on Laboratory Findings at Dr. Soetomo Hospital, Indonesia. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 6: Nov – Dec 2025, Pages 1293-1301 URL: https://www.ijscia.com/wp-content/uploads/2025/12/Volume6-Issue6-Nov-Dec-No.1008-1293-1301.pdf
Volume 6 | Issue 6: Nov – Dec 2025
