The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
Renata Morais Ferreira Amorim1, Messias Vital de Oliveira2, Benildo Sousa Cavada2, Kyria Santiago Nascimento2, Ana Maria S. Assreuy1* and Alana de Freitas Pires3
Abstract
The involvement of endocannabinoid receptors in the antinociceptive activity of Lonchocarpus araripensis lectin (LAL) was investigated in the model of carragenan-induced hypernociception. Swiss mice received LAL (10 mg/kg) by intravenous (i.v.) route 30 min before subcutaneous (s.c.) injection of carrageenan in the paws. Animals were treated with the antagonists of CB1 (AM251) or CB2 (AM630) cannabinoid receptors 30 min before the lectin. LAL inhibited the hypernociception induced by carrageenan (1 h: 11.87 ± 0.61 g; 3 h: 9.7 ± 0.70 g). AM251 (1 h: 4.75 ± 0.41 g; 3 h: 4.5 ± 0.53 g) and AM630 (1 h: 5.67 ± 0.56 g; 3 h: 5 ± 0.68 g) reversed the inhibitory effect of LAL. The antinociceptive effect of Lonchocarpus araripensis lectin is mediated by endocannabinoid receptors.
Keywords:
Dalbergieae lectin; hipernociception; cannabinoid receptors
Cite This Article
Amorim, R. M. F., Oliveira, M.V. d., Cavada, B. S., Nascimento, K. S., Assreuy, A. M. S., Pires, A. d. F. (2021). The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors. International Journal of Scientific Advances (IJSCIA), Volume 2| Issue 4: Jul-Aug 2021, Pages 587-590 , URL: https://www.ijscia.com/wp-content/uploads/2021/08/Volume2-Issue4-Jul-Aug-No.132-587-590.pdf
Volume 2 | Issue 4: Jul-Aug 2021
ISSN: 2708-7972
This work is licensed under a Creative Commons Attribution 4.0 (International) Licence.(CC BY-NC 4.0).
