High Serum S100B Protein Levels As A Predictor Of Cognitive Function Disorders In Moderate Traumatic Brain Injury Patients

Ni Made Kurnia Dwi Jayanthi, Anak Agung Ayu Putri Laksmidewi*, Anna Marita Gelgel, Anak Agung Raka Sudewi, Desak Ketut Indrasari Utami, Ketut Widyastuti, and I Wayan Niryana

Abstract

Objective: To prove high serum S100B protein levels as a predictor of impaired cognitive function in patients with moderate traumatic brain injury. Method: A prospective cohort analytic observational study. The subjects are patients with a moderate degree of TBI with inclusion criteria: onset of TBI 24 hours, age 17-40 years old, and the exclusion criteria were the presence of impaired cognitive function pre-traumatic brain injury (Short IQCODE) 3), depression and multiple trauma. Patients/families/guardians who agreed to the informed consent were checked for S100B levels at <24 hours, then matched with the Montreal Cognitive Assessment version Indonesia (MoCA-INA) questionnaire on day 14 after TBI. This study’s data analysis consisted of univariate and bivariate analysis using Chi-Square. The significance level is stated with p <0.05, 95% confidence interval (CI) assisted by the IBM SPSS version 23. Results: There were 43 research subjects; 23 in the high S100B group and 20 in the S100B group were not high. The mean age is 28 years, with a ratio of 4:1 for men and females. Most of the years, education ≥12 years. The incidence of cognitive dysfunction in patients with moderate traumatic brain injury in the high serum S100B group was 76.19%, while in the non-high serum S100B group was 23.80%, with RR = 6.85, with 95% CI between 1.78-26 .36, and p-value = 0.005. Conclusion: High serum S100B protein levels as a predictor of cognitive function disorders were statistically significant in moderate traumatic brain injury patients with a risk of 6.85 times.

Keywords

traumatic brain injury; S100 B protein levels; impaired cognitive function

Cite This Article

Jayanthi, N. M. K. D., Laksmidewi, A. A. A. P., Gelgel, A. M., Sudewi, A. A. R., Utami, D. K. I., Widyastuti, K., Niryana, I. W. (2023). High Serum S100B Protein Levels As A Predictor Of Cognitive Function Disorders In Moderate Traumatic Brain Injury Patients. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 3: May-Jun 2023, Pages 326-332, URL: https://www.ijscia.com/wp-content/uploads/2023/05/Volume4-Issue3-May-Jun-No.434-326-332.pdf

Volume 4 | Issue 3: May-Jun 2023