Nutritional Supplementation and High-Intensity Exercise: A Systematic Review
I Gusti Ayu Indira Pratiwi1*, Agustinus I Wayan Harimawan2
Abstract
High-intensity interval training and resistance training provide significant benefits for physical performance but may induce oxidative stress and inflammation. Nutritional strategies have been proposed to mitigate these effects. This systematic review aimed to evaluate the effects of nutritional supplementation combined with high-intensity interval training or resistance training on oxidative stress, inflammatory markers, recovery, and performance outcomes in healthy adults. A systematic search was conducted in PubMed, Scopus, and Web of Science. Eligible studies included randomized controlled trials in humans investigating nutritional supplementation in combination with high-intensity interval training or resistance training. Study selection followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Six studies met the inclusion criteria. Polyphenol supplementation combined with resistance training improved muscle mass and maximal oxygen uptake but showed limited anti-inflammatory effects. Acute L-citrulline supplementation increased nitric oxide and antioxidant enzyme activity after high-intensity interval training. Green tea combined with high-intensity interval training reduced interleukin-6, interleukin-1 beta, and galanin while enhancing antioxidant activity in obese older adults. Vitamins C and E reduced muscle damage and hemolysis in elite athletes. Probiotics improved recovery and reduced inflammatory responses. Nutritional supplementation, particularly L-citrulline and polyphenols, shows potential to enhance antioxidant defense, reduce inflammation, and support recovery when combined with high-intensity interval or resistance training.
Keywords
high-intensity interval training; nutritional supplementation; antioxidants; inflammatory response
Cite This Article
Pratiwi, I. G. A. I., Harimawan, A. I. W. (2026). Nutritional Supplementation and High-Intensity Exercise: A Systematic Review. International Journal of Scientific Advances (IJSCIA), Volume 7| Issue 2: Mar – Apr 2026, Pages 233-242 URL: https://www.ijscia.com/wp-content/uploads/2026/03/Volume7-Issue2-Mar-Apr-No.1037-233-242.pdf
Volume 7 | Issue 2: Mar – Apr 2026
