Osteosarcoma Profile in Dr. Soetomo General Academic Hospital Surabaya: A 5-year Retrospective
Khafidhotul Ilmiah1,2*, Heriyawati1,2
Abstract
Background: Osteosarcoma is the most common primary malignant bone tumor in adolescents and young adults. Pathological assessment plays a pivotal role in confirming the diagnosis and evaluating treatment response. However, comprehensive data describing the clinicopathological profile of osteosarcoma based on the type of surgical specimen remains limited. Objective: This study aims to characterize the clinicopathological features, histologic subtypes, and distribution of osteosarcoma from various surgical specimens and their pre-operative chemotherapy response. Method: This is a descriptive study with a retrospective design. Data were collected from the histopathological diagnosis of osteosarcoma from various surgical procedures at the Laboratory of Anatomical Pathology in Dr. Soetomo General Academic Hospital, Surabaya, from January 2020 to May 2025. Result: A total of 89 osteosarcoma cases were analyzed, comprising 61 males (68.5%) and 28 females (31.5%), with the majority occurring in the 11–20-year age group. The femur and tibia were the most frequently involved sites. Amputation was the predominant surgical procedure (52.8%). Conventional osteosarcoma accounted for 92.1% of all histologic subtypes. Only 32.2% of patients received preoperative chemotherapy, and most exhibited low Huvos grades (I–II), reflecting limited histologic response to treatment. Discussion: Osteosarcoma predominantly affects young males and commonly arises in the metaphyseal regions of long bones, particularly the femur and tibia, in this study. Low Huvos grade observed in most cases suggests suboptimal response to preoperative chemotherapy, underscoring the urgent need for earlier diagnosis and improved multimodal management. Conclusion: comprehensive histopathological evaluation remains pivotal for prognostic assessment.
Keywords
cancer; bone tumor; resection; amputation; limb ablation.
Cite This Article
Ilmiah, K., Heriyawati. (2025). Osteosarcoma Profile in Dr. Soetomo General Academic Hospital Surabaya: A 5-year Retrospective. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 5: Sep – Oct 2025, Pages 940-944 URL: https://www.ijscia.com/wp-content/uploads/2025/10/Volume6-Issue5-Sep-Oct-No.955-940-944.pdf
Volume 6 | Issue 5: Sep – Oct 2025
