Renal Amyloidosis Presenting as Nephrotic Syndrome and Hypotension
Syeda Juveria Hussaini¹, Rajaram Jagdale2*
Abstract
Background: Renal amyloidosis is a rare cause of nephrotic syndrome, often presenting with heavy proteinuria, hypoalbuminemia, and progressive renal dysfunction. Systemic involvement may lead to autonomic dysfunction and persistent hypotension, posing diagnostic and therapeutic challenges. Case Presentation: We report a 52-year-old male who presented with frothy urine, edema, and persistent low blood pressure. Laboratory investigations revealed nephrotic-range proteinuria (urine microalbumin 5799 mg/L), severe hypoalbuminemia (1.9 g/dL), hypercholesterolemia, and preserved renal function (serum creatinine 1.2 mg/dL). Ultrasound showed normal-sized kidneys with preserved parenchyma. Renal biopsy confirmed primary renal amyloidosis. Despite corticosteroids, midodrine, diuretics, and albumin infusion, the patient continued to experience symptomatic hypotension, likely secondary to autonomic dysfunction. Conclusion: This case highlights the importance of early renal biopsy in unexplained nephrotic syndrome and underscores the role of autonomic dysfunction in renal amyloidosis. Multidisciplinary management is essential for improved outcomes.
Keywords
Renal Amyloidosis; Nephrotic Syndrome; Hypotension; Membranous Glomerulonephritis; Autonomic Dysreflexia.
Cite This Article
Hussaini, S. J., Jagdale, R. (2025). Renal Amyloidosis Presenting as Nephrotic Syndrome and Hypotension. International Journal of Scientific Advances (IJSCIA), Volume 6| Issue 4: Jul – Aug 2025, Pages 824-825 URL: https://www.ijscia.com/wp-content/uploads/2025/08/Volume6-Issue4-Jul-Aug-No.935-824-825.pdf
Volume 6 | Issue 4: Jul – Aug 2025
