A Systematic Literature Review of Neurofibromatosis Type 1 Ni Putu Sevina Lovyanti1, Joni Wahyuhadi2*, Dyah Fauziah3, Rahadian Indarto Susilo2 Abstract Background: Neurofibromatosis type 1 is an autosomal disease caused by a mutation on chromosome 17, resulting in several clinical manifestations outlined in the diagnostic criteria and affecting other organ systems.