Cardiac Involvement in Childhood-Onset Systemic Lupus Erythematosus: A Literature Review of Pathophysiology, Diagnosis, and Management Marvelle Jocellyne Aubrey Lee1, Azwin Mengindra Putera2* Abstract Systemic lupus erythematosus (SLE) is an autoimmune disorder that arises from a loss of immune tolerance and damages many organs through autoantibodies, immune-complex deposition, and inflammation. Childhood-onset