The Relationship Between Neutrophil Lymphocyte Ratio and C-Reactive Protein with Depression and Quality of Life in Non-Small-Cell Lung Cancer Patient
Luh Komang Ayu Widhiaty Karang1, Ida Ayu Jasminarti Dwi Kusumawardani1, Ni Ketut Putri Ariani2, I Gede Ketut Sajinadiyasa1, Ni Wayan Candrawati1, Ni Luh Putu Eka Arisanti1, Ida Bagus Ngurah Rai1
Abstract
Background: Lung cancer is a global problem and the second most common cancer case for newly diagnosed cancers in 2020. Lung cancer is related to the inflammatory process, and symptoms of depression are often found in lung cancer patients. Improving the quality of life is one of the goals in advanced lung cancer treatment. This study aims to find the relationship between increased inflammatory markers such as neutrophil lymphocyte ratio (NLR), c-reactive protein (CRP) and depression with quality of life in patients with advanced non-small cell lung carcinoma. Methods: This was an observational analytic study conducted using a cross sectional design at Prof. Ngoerah Denpasar General Hospital (November 2022-August 2023). Univariate analysis presents data in the form of frequency, mean and standard deviation. Bivariate analysis was performed using the Chi-Square test and multivariate analysis using logistic regression. Results: The total samples in this research were 110 samples. The results of bivariate analysis showed that there was a significant relationship between NLR and CRP with depression (OR=3.225, p=0.005; OR=4.645, p=0.001), NLR and CRP with quality of life (OR=4.46, p=0.003; OR=5.313, p<0.001) and depression with quality of life (OR=31.385, p=<0.001). The results of multivariate analysis showed that NLR and CRP are independent risk factors for depression and decreased quality of life in patients with advanced non-small cell lung carcinoma. There was also a significant influence of age on the occurrence of depression (OR=0.364, p=0.037) and the influence of histology type (OR=0.493 p=0.039) on the quality of life of lung cancer patients. Conclusion: There was significant relationship between NLR and CRP with depression and quality of life in patients with advanced non-small cell lung carcinoma. Beside inflammatory markers, age is also related to the occurrence of depression and the type of histology influences quality of life.
Keywords
NLR; CRP; depression; quality of life; advanced non-small cell lung carcinoma
Cite This Article
Karang, L. K. A. W., Kusumawardani, I. A. J. D., Ariani, N. K. P., Sajinadiyasa, I. G. K., Candrawati, N. W., Arisanti, N. L. P. E., Rai, I. B. N. (2023). The Relationship Between Neutrophil Lymphocyte Ratio and C-Reactive Protein with Depression and Quality of Life in Non-Small-Cell Lung Cancer Patient. International Journal of Scientific Advances (IJSCIA), Volume 4| Issue 6: Nov-Dec 2023, Pages 838-851, URL: https://www.ijscia.com/wp-content/uploads/2023/11/Volume4-Issue6-Nov-Dec-No.517-838-851.pdf
Volume 4 | Issue 6: Nov-Dec 2023
