The Relationship Between Obesity And 3-Year Overall Survival in Luminal B HER2-Negative Breast Cancer Patients Receiving Neoadjuvant Chemotherapy at Prof. Dr. I.G.N.G Ngoerah Hospital
Felicia Adelina Shannen1*, Ida Bagus Made Suryawisesa2, I Made Mulyawan3, Putu Anda Tusta Adiputra2, I Gede Budhi Setiawan2, Gede Eka Rusdi Antara3
Abstract
Background: Luminal B breast cancer is the second most common subtype, with a relatively high mortality rate. The luminal B HER2-negative subtype shows a 26% survival rate over 5 years. One of the factors that can influence survival in breast cancer patients is obesity. Obesity is a public health issue that requires strong preventive intervention strategies, especially among patients diagnosed with breast cancer. Methods: This study is a survival analysis aiming to find a significant relationship between obesity and 3-year overall survival in Luminal B HER2-negative breast cancer patients receiving neoadjuvant chemotherapy at Prof. Dr. I.G.N.G Ngoerah Hospital. The data were retrospectively reviewed. The target population includes Luminal B HER2-negative breast cancer patients. Data analysis was performed using SPSS, including Chi-Square tests, Independent T-Tests, and Kaplan-Meier survival analysis. Results: In this study, 57 subjects were divided into 2 groups: the obese group, consisting of 25 subjects, and the non-obese group, consisting of 32 subjects. The results showed that the non-obese group experienced higher mortality rates compared to the obese group (68.8% vs. 32.0%; p=0,006). Obese patients had a significantly lower risk of death, with an odds ratio of 0.465 (95% CI 0.251-0.863; p=0,006), compared to non-obese patients. The Kaplan-Meier analysis indicated that the 3-year overall survival rate was higher in the obese group compared to the non-obese group, with a median survival of 60 months (95% CI 51-70 months) versus 49 months (42-56 months), LRT 4.098, p=0.043. Conclusion: There is a significant relationship between obesity and 3-year overall survival in Luminal B HER2-negative breast cancer patients receiving neoadjuvant chemotherapy at Prof. Dr. I.G.N.G Ngoerah Hospital.
Keywords
breast cancer HER2-negative; Luminal B; neoadjuvant chemotherapy; survival
Cite This Article
Shannen, F. A., Suryawisesa, I. B. M., Mulyawan, I. M., Adiputra, A. T., Setiawan, I. G. B., Antara, G. E. R. (2026). The Relationship Between Obesity And 3-Year Overall Survival in Luminal B HER2-Negative Breast Cancer Patients Receiving Neoadjuvant Chemotherapy at Prof. Dr. I.G.N.G Ngoerah Hospital. International Journal of Scientific Advances (IJSCIA), Volume 7| Issue 2: Mar – Apr 2026, Pages 227-232 URL: https://www.ijscia.com/wp-content/uploads/2026/03/Volume7-Issue2-Mar-Apr-No.1036-227-232.pdf
Volume 7 | Issue 2: Mar – Apr 2026
